Fresh analysis indicates that individuals who come off popular slimming jabs like Wegovy and Mounjaro can put back on reduced body mass far faster than those who stop conventional lifestyle regimens.
Findings released in a major medical journal demonstrates that while overweight individuals often shed about a fifth of their body weight while on the medication, the mass is regained at an average rate of nearly a kilo each month after stopping.
"Individuals purchasing such medications must be informed of the danger of rapid rebound weight gain when the treatment concludes," cautioned researcher Dr. Susan Jebb.
Such speed of recovery means a return to starting weight in about a year and a half.
Analyzing Therapies
The study, which reviewed dozens of trials involving over 9,000 of patients, contrasted the effects of these new drugs with conventional dieting.
Researchers note that people who lose weight through dieting generally see a more gradual weight regain—perhaps 100 grams monthly—after stopping.
The Reason for the Quick Regain
Nutrition scientists suggest the mechanism of the drugs explains the amplified regain.
These medications imitate a natural hormone called glucagon-like peptide-1, which helps regulate hunger.
"Long-term administration of GLP-1 levels several times higher than normal might result in the system to generate a reduced amount of its endogenous hormone, and could reduce sensitivity to its actions," said Dr. Adam Collins, a dietetics expert.
"Stopping of this GLP-1 'fix' means appetite is no longer kept in check, making overeating a significant risk."
A Chronic Disease?
The NHS advise the jabs for individuals with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
Professionals contend that, considering the likelihood of relapse, the treatment might need to be ongoing.
This view is supported by pharmaceutical companies, who note that the results "emphasize the persistent nature of excess weight," akin to managing diseases like high blood pressure.
User Experiences
Users who have come off the medication report a sudden resurgence of hunger.
"I experienced something activating and you become starving," said a patient.
The struggle is worsened if patients have not developed permanent dietary or behavioural modifications during therapy.
Growing Interest
Figures suggest that a significant number of people in the UK have used these injections in the last 12 months, with desire remaining high.
- Use is greater among females than men.
- The middle-aged age group shows the greatest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than public health services.
In conclusion, researchers emphasize that while these medications are powerful agents for shedding pounds, they are not a permanent cure and lasting health benefits relies on ongoing lifestyle support.
